The diagnosis of insulitis in human type 1 diabetes

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منابع مشابه

Spatiotemporal Dynamics of Insulitis in Human Type 1 Diabetes

Type 1 diabetes (T1D) is an auto-immune disease characterized by the selective destruction of the insulin secreting beta cells in the pancreas during an inflammatory phase known as insulitis. Patients with T1D are typically dependent on the administration of externally provided insulin in order to manage blood glucose levels. Whilst technological developments have significantly improved both th...

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Insulitis in Type 1 Diabetes: A Sticky Problem

Lymphocytic infiltration in the islets of Langerhans is generally recognized as the defining lesion in young patients with recent-onset type 1A diabetes. In a landmark article published in Diabetes in 1965, Gepts (1) described insulitis in 70% of cases with acute diabetes and found that the lesion only affected islets with residual -cells in pancreatic organs that had otherwise lost most of the...

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ژورنال

عنوان ژورنال: Diabetologia

سال: 2013

ISSN: 0012-186X,1432-0428

DOI: 10.1007/s00125-013-3043-5